Accession Number:

ADA413295

Title:

Control of Alcoholism-Related Folate Deficiency by Regulation of Urinary Folate Excretion

Descriptive Note:

Annual rept. 1 Oct 2001-30 Sep 2002

Corporate Author:

LOUISIANA STATE UNIV IN SHREVEPORT HEALTH SCIENCE CENTER

Personal Author(s):

Report Date:

2002-10-01

Pagination or Media Count:

45.0

Abstract:

Health-related consequences of heavy drinking include nutritional deficiencies. Folate deficiency occurs from multiple causes including increased urinary folate excretion. Ethanol decreases the renal reabsorption of folate leading to increased excretion The main aim of this research is to determine the mechanism by which ethanol decreases folate transport by the kidney. Initially the effects of ethanol on expression of the two renal transport proteins the folate receptor FR and the reduced folate carrier RFc were determined in vivo and in vitro.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE