Accession Number:

ADA413292

Title:

Malaria Genome Sequencing Project

Descriptive Note:

Annual rept. 17 Dec 2001-16 Dec 2002

Corporate Author:

INSTITUTE FOR GENOMIC RESEARCH ROCKVILLE MD

Personal Author(s):

Report Date:

2003-01-01

Pagination or Media Count:

52.0

Abstract:

The objectives of this 5-year Cooperative Agreement between TTGR and the Malaria Program, NMRC, were to Specific Aim 1, sequence 3.5 Mb of P. falciparum genomic DNA Specific Aim 2, annotate the sequence Specific Aim 3, release the information to the scientific community. Two additional Specific Aims were added to the Cooperative Agreement Specific Aim 4, sequencing of P. yoelii to 5X coverage Specific Aim 5, sequencing of P. vivax to 5X coverage. This year we reached a major milestone by publishing, in collaboration with the Sanger Institute and Stanford University, the complete genome sequence of P. falciparum in the journal Nature. In addition, we published a comparative analysis of the genome of the rodent malaria parasite P. yoelii with that of p. falciparum. We began sequencing of the second major human malaria parasite P. vivax and attained 5X coverage of the genome. We obtained additional funds from other sources to permit the sequencing of P. vi vax to 8X coverage, to close one-third of the genome, and to annotate the genome and compare it to the genomes of P. falciparum and P. yoelii. This work will be completed under a 12-month no-cost extension of this Cooperative Agreement. Discussions with the Malaria Program, NMRC aimed at development of a program to use genomics and functional genomics to accelerate vaccine research are in progress.

Subject Categories:

  • Genetic Engineering and Molecular Biology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE