Accession Number:

ADA413282

Title:

Magnetic Resonance Arterial Spin Tagging for Non-Invasive Pharmacokinetic Analysis of Breast Cancer

Descriptive Note:

Final rept. 30 Sep 1997-29 Sep 2002

Corporate Author:

CALIFORNIA UNIV DAVIS

Personal Author(s):

Report Date:

2002-10-01

Pagination or Media Count:

64.0

Abstract:

This research project focused on the development of MRI arterial spin tagging to non-invasively measure breast tissue perfusion. The specific aims were to 1 refine arterial spin tagging pulse sequences, 2 develop automated data analysis software, and 3 compare the technique to first-pass contrast-enhanced MRI and biopsy. New spin-tagging pulse sequences were developed for the GE 1.5T Advantage and Horizon LX CVI MRI systems, and new image processing software, including software for statistical analysis of spin tagging and contrast enhanced dynamic scans, were written for use in the clinical setting. Year three and no-cost extension years of the project focused on clinical comparison of arterial spin tagging with first-pass, contrast-enhanced MRI in patients with unbiopsied breast masses, for aim.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE