Accession Number:

ADA413199

Title:

A Laboratory Evaluation of Performance Following a Daytime Nap Under Zaleplon and Placebo Conditions

Descriptive Note:

Final rept. 1 Jan 2001-7 Apr 2003

Corporate Author:

AIR FORCE RESEARCH LAB BROOKS AFB TX HUMAN EFFECTIVENESS DIR/BIODYNAMICS ANDPROTECTION DIV

Report Date:

2003-04-01

Pagination or Media Count:

43.0

Abstract:

Primary objective was to determine if zaleplon 10-mg negatively impacted human performance, compared to placebo, after a sudden awakening from a short period 1 hour of daytime sleep 16 volunteers, 8 males and 8 females, were formed into 4 groups of 4 participants each. The study used a repeated measures design with 2 within-subject factors drug and trial. Each participant experienced both drug conditions. Drug administration was counterbalanced and double-blinded. Performance measures cognition and memory, balance, strength and subjective reports were collected during every waking hour. Performance was significantly negatively impacted in the zaleplon condition up to 3-hrs post-dose. A few measures remained significantly below baseline at 3-hrs post-awakening. All measures returned to baseline by 4-hrs post-awakening. Caution is advised regarding daytime zaleplon use in operational settings involving extreme environments or emergency procedures that include higher cognitive tasks. Findings support insertion of a minimum of lO-min recovery time prier to any work activities following a daytime nap.

Subject Categories:

  • Psychology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE