Novel Resuscitation from Lethal Hemorrhage - Suspended Animation for Delayed Resuscitation
Final rept. 15 Aug 2001-14 Aug 2002
PITTSBURGH UNIV PA
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We have been working since the 1980s, for the past 4 years under DOD support, on novel ways to resuscitate unresuscitable trauma victims. We focus on combat casualties who exsanguinate internally within a few minutes to cardiac arrest. We have conceived and documented suspended animation for delayed resuscitation with the use of hypothermic saline flush into the aorta within the first 5 minute of no blood flow, using novel clinically relevant outcome models in dogs. With the use of saline flush we have achieved resuscitation with cardiopulmonary bypass to complete recovery after circulatory arrests of up to 90 min at 10 degrees C. This is the report on year 4. In year 4, study I, with the use of novel solutions Normosol, Unisol, Tempol, we achieved such success after up to 120 min no-flow. That had been so far with models not including severe tissue trauma.
- Medicine and Medical Research