Accession Number:

ADA411959

Title:

The Role of Human Spectrin SH3 Domain Binding Protein 1 (HSSH3BP1) in Prostatic Adenocarcinoma

Descriptive Note:

Annual rept. 20 Aug 2001-19 Aug 2002

Corporate Author:

RESEARCH FOUNDATION FOR MENTAL HYGIENE ALBANY NY

Report Date:

2002-09-01

Pagination or Media Count:

10.0

Abstract:

Prostate cancer is one of the leading causes of cancer-related deaths in the United States and a leading - diagnosed cancer in American men. Newly diagnosed cases of prostate cancer approach rapidly the number of 200, 000 cases per year. Genetic alterations of tumor suppressor genes are one of the most common causes of prostate cancer tumorigenesis. Our group identified Hssh3bp1 as a candidate prostate tumor suppressor gene. In this research we are testing the tumor suppressor function of the candidate gene in pro static adenocarcinoma using in vitro and in vivo assays. Expression of Hssh3bp1 significantly decreased growth of LnCAP cells in vitro suggesting that Hssh3bp1 may be critical for regulation of growth of prostate tissue.

Subject Categories:

  • Biochemistry
  • Genetic Engineering and Molecular Biology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE