Accession Number:

ADA411955

Title:

The Role of Steroid Receptor Coactivators (SRCs) in the Development of Prostate Cancer

Descriptive Note:

Annual rept. 15 Aug 2001-14 Aug 2002

Corporate Author:

BAYLOR COLL OF MEDICINE HOUSTON TX

Personal Author(s):

Report Date:

2002-09-01

Pagination or Media Count:

15.0

Abstract:

In prostate cancer, androgen receptor AR supervises several key genes expressions. In the cell. AR exerts its regulatory control on a target cell only in the presence of its cognate ligand, androgen. The regulatory functions of AR are more complex and are fine-tuned by accessory proteins. These proteins are required for the maximum biological impact by androgen. These modulators, called coactivators, provide a positive stimulus for receptor action. Our laboratory has cloned the first nuclear receptor coactivators such as SRC-1, -2, and -3. They have the capacity to activate the transcriptional activity of steroid receptor. However, the role of steroid receptor coactivators in prostate gland is still unclear.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE