The Role of Steroid Receptor Coactivators (SRCs) in the Development of Prostate Cancer
Annual rept. 15 Aug 2001-14 Aug 2002
BAYLOR COLL OF MEDICINE HOUSTON TX
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In prostate cancer, androgen receptor AR supervises several key genes expressions. In the cell. AR exerts its regulatory control on a target cell only in the presence of its cognate ligand, androgen. The regulatory functions of AR are more complex and are fine-tuned by accessory proteins. These proteins are required for the maximum biological impact by androgen. These modulators, called coactivators, provide a positive stimulus for receptor action. Our laboratory has cloned the first nuclear receptor coactivators such as SRC-1, -2, and -3. They have the capacity to activate the transcriptional activity of steroid receptor. However, the role of steroid receptor coactivators in prostate gland is still unclear.
- Medicine and Medical Research