Effects of Surface Chemistry and Protein Competitive Adsorption on Cell Adhesion
CHINESE ACADEMY OF SCIENCES BEIJING NATIONAL MICROGRAVITY LAB
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The competitive adsorption between collagen and bovine serum albumin BSA was investigated by imaging ellipsometry. The competitive adsorption of the binary solution depended on the surface chemistry of substrates, At the range of concentration investigated, collagen preferentially adsorbed on the hydroxy surface -OH surface but BSA on the methylic surface -CH3 surface, ROS 172.8 cell adhesion on the two kinds of surfaces with or without the pre-adsorption of protein was also investigated, The results showed that the competitive adsorption caused ROS 172.8 cells preferentially adhered and spread well on the -OH surface, but less adhered and didnt spread on the -CH3 surface.