Accession Number:

ADA411832

Title:

Soft Lithography for Oligonucleotide Arrays Fabrication

Descriptive Note:

Conference paper

Corporate Author:

SOUTHEAST UNIV NANJING (CHINA) MINISTRY OF EDUCATION FOR MOLECULAR AND BIOMOLECULAR ELECTRONICS

Personal Author(s):

• Xiao, P. F.
• He, N. Y.
• He, Q. G.
• Liu, ZS. C.
• Liu, Z. H.

Report Date:

2001-10-25

Pagination or Media Count:

5.0

Abstract:

A method for fabricating high-density oligonucleotide arrays directed by a set of molecular stamp was reported in this paper. In this method, based on the standard phosphoramidites chemistry protocol, the coupling was conducted under soft lithography. A 20-mer DNA microarray with 10,000 probes has been successfully fabricated, which shows the advantages of accurate, reliable operation and low-cost production of high-density DNA chip.

Descriptors:

• *LITHOGRAPHY
• *NUCLEOTIDES
• SYMPOSIA
• SYNTHESIS(CHEMISTRY)
• GENETICS
• CHINA
• MICROMACHINING

Subject Categories:

• Biochemistry
• Genetic Engineering and Molecular Biology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE