Accession Number:

ADA411798

Title:

Involvement of Tyrosine Phosphatases in Insulin Signaling and Apoptosis in Breast Cancer

Descriptive Note:

Annual rept. 1 Jun 2001-31 May 2002

Corporate Author:

M D ANDERSON CANCER CENTER HOUSTON TX

Personal Author(s):

Report Date:

2002-06-01

Pagination or Media Count:

22.0

Abstract:

Our preliminary studies demonstrated that increased intracellular calcium activates calpain to induce partial proteolysis and cytoplasmic translocation of PTP1B, a tyrosine phosphatase proposed to regulate signaling by insulin, IGF-1 and other cytokines. Cytoplasmic translocation of PTP1B results in a distinct pattern of protein tyrosine phosphorylation and these events may regulate cell growth or apoptosis by reducing activated growth factor signaling. In this scheme, calcium-mediated apoptosis and growth inhibition may be directed through mobilization of PTP1B.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE