Involvement of Tyrosine Phosphatases in Insulin Signaling and Apoptosis in Breast Cancer
Annual rept. 1 Jun 2001-31 May 2002
M D ANDERSON CANCER CENTER HOUSTON TX
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Our preliminary studies demonstrated that increased intracellular calcium activates calpain to induce partial proteolysis and cytoplasmic translocation of PTP1B, a tyrosine phosphatase proposed to regulate signaling by insulin, IGF-1 and other cytokines. Cytoplasmic translocation of PTP1B results in a distinct pattern of protein tyrosine phosphorylation and these events may regulate cell growth or apoptosis by reducing activated growth factor signaling. In this scheme, calcium-mediated apoptosis and growth inhibition may be directed through mobilization of PTP1B.
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