Accession Number:

ADA411794

Title:

Influence of a Single-bout of Muscle Damaging Eccentric Exercise on Human Plasma Fibronectin Level

Descriptive Note:

Technical rept.

Corporate Author:

ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA

Report Date:

2002-10-01

Pagination or Media Count:

21.0

Abstract:

Exposure of U.S. Army personnel to strenuous physical stress under harsh environments is often a necessary circumstance to accomplish a military mission. Such exposure can significantly contribute to the casualty rate. To reduce casualties, physiological markers are required to characterize training programs relative to their capacity to impart resistance to the lethal effects of stress. The reticuloendothelial system RES is known to influence survival following injuries associated with shock due to significant blood loss andor tissue damage TD, both of which are possible consequences of combat. Studies in research animals have demonstrated elevated RES clearance function imparts reductions in heat shock mortality. Moreover, a circulating blood constituent, plasma fibronectin PF that mediates RES clearance, when elevated correlates with enhanced heat shock survival. Iii humans, physical exertion repeated over a number of days or weeks in a warm environment induces heat acclimation HA and significantly increases PF, while passive exposure to seasonal change fails to impart HA or elevations in PF.

Subject Categories:

  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE