Accession Number:

ADA411792

Title:

Breast Tumor pH: Design Evaluation and Application of Novel Reporter Molecules

Descriptive Note:

Annual rept. 1 Oct 2001-30 Sep 2002

Corporate Author:

TEXAS UNIV AT DALLAS SOUTHWESTERN MEDICAL CENTER

Personal Author(s):

Report Date:

2002-10-01

Pagination or Media Count:

20.0

Abstract:

Systemic drugs are one of the most potent means for controlling breast cancer. Their ability to kill cancer cells often depends, however, on the presence of appropriate physiological conditions. For instance, exciting recent results suggest that uptake and retention of 5-fluorouracil 5-FU in tumors may be influenced by pH, in particular, the trans membrane pH gradient. This opens the possibility of predicting which tumors will show best response by measuring pH a priori or modulating tumor physiology to optimize tumor selectivity.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE