Breast Tumor pH: Design Evaluation and Application of Novel Reporter Molecules
Annual rept. 1 Oct 2001-30 Sep 2002
TEXAS UNIV AT DALLAS SOUTHWESTERN MEDICAL CENTER
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Systemic drugs are one of the most potent means for controlling breast cancer. Their ability to kill cancer cells often depends, however, on the presence of appropriate physiological conditions. For instance, exciting recent results suggest that uptake and retention of 5-fluorouracil 5-FU in tumors may be influenced by pH, in particular, the trans membrane pH gradient. This opens the possibility of predicting which tumors will show best response by measuring pH a priori or modulating tumor physiology to optimize tumor selectivity.
- Medicine and Medical Research