Accession Number:

ADA411750

Title:

Precursors to Rapid Elevations in Intracranial Pressure

Descriptive Note:

Conference proceedings

Corporate Author:

PORTLAND STATE UNIV OR BIOMEDICAL SIGNAL PROCESSING LAB

Report Date:

2001-10-25

Pagination or Media Count:

5.0

Abstract:

Intracranial pressure ICP monitoring and management have substantially improved the outcome of patients with traumatic brain injury TBI. However, rapid elevations in ICP remain a significant problem as they may lead to secondary brain injury and worse outcome due to cerebral ischemia. Current therapy is targeted towards treating rapid ICP elevations after they occur. Ideally, anticipation treatment to obviate any elevation in ICP could occur if reliable precursors to ICP elevation were determined. In this paper, we report evidence for a physiologic transition zone prior to rapid elevations in ICP. We found that in thirty-three episodes of ICP elevation recorded from eleven patients, there was a statistically consistent decrease in the cardiac component of the ICP signal and the coefficient of correlation between the ICP trend and the pulse amplitude. We conclude that specific ICP signal metrics may serve as precursors that characterize the transition zone prior to a rapid elevation and may enable prediction of these elevations up to thirty seconds ahead.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE