Assessing Vascular Oxygen Dynamics for Breast Tumor Prognosis: Comparison Between MR BOLD and Near Infrared Method
Annual summary rept. 1 Sep 2001-31 Aug 2002
TEXAS UNIV AT ARLINGTON
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The goal of this research project is to investigate vascular oxygen dynamics in breast tumors by correlating the results of NIRS and BOLD in MRI. I have compared simultaneous measurements of three oxygen-related indicators arterial hemoglobin oxygen saturation SaO2, tumor vascular oxygenated hemoglobin concentration HbO2, and tumor oxygen tension P02 by a pulse oximeter, NIRS and optic fiber needle system FOXYTM, respectively. The consistence of the three oxygen-related parameters in evaluating the dynamic response of oxygen level in breast tumors to hyperoxic inspiratory treatment demonstrated the capability of NIRS as a noninvasive, real time monitoring tool for tumor vascular oxygenation. With this convinced NIRS, I monitored the dynamic responses of HbO2J to different interventions for optimizing modalities in breast tumor treatment. Results showed that hyperoxic gases, carbogen and oxygen, can repeatedly and effectively elevate the oxygen level in breast tumors, without significant difference in magnitude of AHbO2. And hydralazine can significant reduce breast tumor vascular AHbO2, independent of gas breathing. The heterogeneity of oxygenation in breast tumors was also investigated by the multi-channel optic fiber needle system FOXYTM.
- Anatomy and Physiology
- Medicine and Medical Research