New PTEN Signal Pathway in Breast Cancer
Annual rept. 1 Jun 2001-31 May 2002
ROCHESTER UNIV NY
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Breast cancer is the most common cancer in women, and the second most common cause of cancer death in women in the United States, but the molecular basis remains unclear. PTEN, a tumor suppressor gene is found deleted or mutated in many human tumors, and regulates cell growth, migration, etc through down-regulation of downstream mediators, such as Akt. Overexpression of PTEN in breast cancer cell lines resulted in cell growth suppression. PTEN may be correlated with a positive ER and PR status in primary breast cancers, as well as AR. Androgens, may inhibit mammary carcinoma growth in animal models and is used as a therapeutic agent. Both PTEN and AR play important roles in the progression of breast cancer, however, the correlation between them remains unknown. Based on our preliminary results, we propose a new PTEN pathway by direct interaction with AR results in the modulation of AR-mediated cell growth. Therefore, this study provides a new molecular mechanism of PTEN-mediated AR suppression signaling pathways, which may modulate the cell growth in breast cancer. The consequence of these results may provide new gene therapies or drug designs for treatment of breast cancer patients in the future.
- Genetic Engineering and Molecular Biology
- Anatomy and Physiology
- Medicine and Medical Research