Magnetic Resonance Spectroscopy Imaging and Functional Magnetic Resonance Imaging of Neurofibromatosis Type 1: In Vivo Pathophysiology, Brain-Behavior Relationships and Reading Disabilities
Annual rept. 1 Oct 2001-30 Sep 2002
KENNEDY KRIEGER RESEARCH INST INC BALTIMORE MD
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The purpose of this research is oriented towards understanding the reading, language, and articulation deficits associated with Neurofibromatosis Type 1 NF-1 and relating these deficits to the underlying pathophysiology of NF-1 as revealed by Magnetic Resonance Spectroscopy Imaging MRSI. A second goal is to determine how differences in activation, as measured by functional Magnetic Resonance Imaging fMRI, are linked to the cognitiveacademic impairments associated with NF-1. A third goal is to further understand how T-2 weighted hyperintensities on Magnetic Resonance Imaging MRI scans are related to cognitiveacademic impairments associated with NF-1.
- Medicine and Medical Research