Quantitative Ischemia Detection During Cardiac MR Stress Testing
JOHNS HOPKINS UNIV BALTIMORE MD SCHOOLOF MEDICINE
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Because ECG alterations due to ischemia cannot he reliably detected in the high-field MRI environment, detection of wall motion abnormalities are often the only method to ensure patient safety. In this study, we investigate the use of real-time Harmonic Phase HARP MRI for the quantitative, operator-independent detection of the onset of ischemia during acute coronary occlusion. Six mongrel dogs underwent acute coronary artery ischemia of 2 minutes duration while continuous HARP MR images were acquired followed by 5 minutes of reperfusion. During a second ischemic episode, conventional cine wall motion images were acquired. The time from occlusion to the detection of ischemia by each MR technique, as well as ECG ischemic alterations, was determined. In 5 of 6 animals, the onset of ischemia was detected significantly earlier by HARP than by cine MRI 11 plus or minus 5 s HARP vs. 34 plus or minus 14.8 s cine, PO.03. HARP ischemia detection preceded ECG changes, on average, by 66 seconds. Cine MRI did not detect ischemia significantly earlier than when ECG changes were apparent P0.11. The rapid acquisition and detection of ischemia using HARP MRI shows promise as a non-subjective method to diagnose significant coronary lesions in patients while ensuring patient safety during stress testing.
- Medicine and Medical Research