Accession Number:

ADA411512

Title:

Receptors, Afferent Signaling and Central Integration in Compensated and Uncompensated Hemorrhagic Shock

Descriptive Note:

Final technical rept. 1 Jan 1997-31 Dec 2002

Corporate Author:

IOWA UNIV IOWA CITY

Personal Author(s):

Report Date:

2003-02-28

Pagination or Media Count:

10.0

Abstract:

An understanding of the central and peripheral mechanisms which regulate sympathetic outflow during acute blood volume loss is critical for developing therapeutic treatments for hemorrhagic shock Insight into the mechanisms by which melanopeptides, LV-HTS, and serotonergic drugs facilitate sympathetic outflow during hemorrhage may lead to the development of pharmacological interventions for hemorrhagic shock. Recent experiments conducted in our laboratory provide important new information about the saluretic effects and mechanisms of 3 potential therapeutic strategies to prevent or reverse phase II shock.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE