Accession Number:

ADA411487

Title:

Breast Cancer Diagnosis Using Ultrasound and Diffusive Light

Descriptive Note:

Annual rept. 15 Aug 2001-14 Aug 2002

Corporate Author:

CONNECTICUT UNIV STORRS

Personal Author(s):

Report Date:

2002-09-01

Pagination or Media Count:

99.0

Abstract:

Tumor blood volume and micro-vascular density are parameters anatomically and functionally associated with tumor angiogenesis. During the last decade, rigorous modeling of the light propagation in the near infrared region, combined with the advancements of light source and detectors, has improved the diffused light measurements and made possible the application of tomographic techniques for characterizing and imaging tumor angiogenesis. If a single wavelength is used, optical absorption related to angiogenesis and other normal blood vessels can be measured. If two or more optical wavelengths are used, both oxy-hemoglobin and deoxy-hemoglobin concentrations can be measured simultaneously. In addition, optical scattering is related to cell activations because scattering is sensitive to any particles that are of the size of the optical wavelength. However, the NIR technique has not been widely used in clinics and the fundamental problem remains the intense light scattering. As a result, diffused light probes a wide region instead of propagating along a straight line. Localization or imaging based on tomographic inverse scattering approaches suffers from low spatial resolution and the inversion problem is, in general, underdetermined and ill-posed.

Subject Categories:

  • Medicine and Medical Research
  • Atomic and Molecular Physics and Spectroscopy
  • Optics

Distribution Statement:

APPROVED FOR PUBLIC RELEASE