Accession Number:

ADA411463

Title:

The RhoC Transgenic Mouse as a Realistic Model of Inflammatory Breast Cancer

Descriptive Note:

Final rept. 15 Sep 2000-14 Sep 2002

Corporate Author:

MICHIGAN UNIV ANN ARBOR

Personal Author(s):

• Van Golen, Kenneth L.

Report Date:

2002-10-01

Pagination or Media Count:

8.0

Abstract:

Inflammatory breast cancer is a unique and highly aggressive form of locally advanced breast cancer. Although it effects a small proportion of women with breast cancer annually in the United States approximately 6, it carries with it the worst prognosis of all breast cancers. Inflammatory breast cancer is unique in the aspect that it invades and grows within the dermal lymphatics of the breast. Blockage of the dermal lymphatics by tumor emboli leads to edema and swelling of the breast, thus giving the appearance of inflammation. The tumor emboli can also metastasize via the dermal lymphatics to the skin of the contralateral breast, chest and stomach.

Descriptors:

• *MAMMARY GLANDS
• *BREAST CANCER
• UNITED STATES
• PREDICTIONS
• NEOPLASMS
• INFLAMMATION
• WOMEN
• EDEMA
• EMBOLISM
• TRANSCRIPTION(GENETICS)

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE