Mammaglobin and Lipophilin Related Molecules in Normal and Tumor Human Breast Tissue: Expression, Hormone Regulation and Functional Analysis
Annual summary rept. 1 Aug 2001-31 Jul 2002
MANITOBA UNIV WINNIPEG
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Improving the diagnosis and clinical management of breast cancer requires access to biomarkers able to reflect the molecular phenotype of breast tissue. Indeed, the knowledge of the genetic changes that manifest themselves as alteration of gene expression occurring during breast tumorigenesis and breast tumor progression, will allow the identification of targets for new preventive and curative strategies. Three such genes are currently studied in our laboratory Mammaglobin MGB1, hSBEM Human Small Breast Epithelial Mucin and SRA Steroid receptor RNA activator. MGB1 expression, previously found to be restricted to breast epithelial cells, is increased in tumor cells compared to normal and correlates with ER levels even though not modified by estrogen or antiestrogen treatment in estrogen positive breast cancer cell lines. We suggest that MOB I could be a new independent breast cancer prognostic marker.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research