Maximizing Immune Responses to Carbohydrate Antigens on Breast Tumors
Annual rept. 15 Jul 2001-15 Jul 2002
PENNSYLVANIA UNIV PHILADELPHIA
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Tumor antigens are autologous antigens and thus are weakly immunogenic. Unresponsiveness appears to be related to suppression of antigen specific helper T cell function which can be overcome by providing heterologous help. Carbohydrates are richly expressed on the surface of many cancers, at frequencies higher than oncogene products. Consequently, tumor associated carbohydrate antigens, are in principle, excellent targets for immunotherapy. However, carbohydrates are generally poor at eliciting effective antibody responses and rarely provide target epitopes for CTL because of their T cell-independent nature. The major objective of this application is to examine ways to maximize the tumor-protective immunity directed to carbohydrate antigens expressed on breast tumors.
- Medicine and Medical Research