The Role of Notch in Regulating Apoptosis in the Mammary Gland
Final rept. 1 Jun 1998-31 May 2002
MASSACHUSETTS UNIV AMHERST
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This proposal is designed to explore the premise that Notch4 signaling may regulate apoptosis in the mammary gland. The specific aims are 1 to determine if nuclear hormone receptors interact with Notch 2 to determine the functional role of Notch and nuclear hormone receptors in tumor formation 3 to elucidate the signaling pathways influenced by potential interactions between Notch and nuclear hormone receptors. We have made significant progress towards understanding the crosstalk between Notch and some of the more important nuclear hormone receptors in the mammary gland.
- Anatomy and Physiology
- Medicine and Medical Research