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Regulation to I Transport in Breast Cancer Cell Lines
Annual summary rept. 1 Jun 2000-30 May 2002
ALBERT EINSTEIN COLL OF MEDICINE OF (YESHIVA UNIV) BRONX NY
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Like thyroid tissue, lactating breast actively accumulates iodide via the NaI- symporter NIS. Iodide is thus supplied to the nursing newborn in the milk. Iodide transport via NIS has been used successfully for over 60 years to treat thyroid cancer by administration of radioiodide. We have shown that over 80 of human breast cancers express NIS, raising the possibility that radioiodide may be used for diagnosis and treatment of breast cancer. The aim of this project was to analyze the distinct regulatory mechanisms exerted on mammary gland NISS in mammary cell lines in vitro. In the last year we demonstrated mgNIS mRNA expression in three non-tumoral and six tumoral breast cell lines, and showed that the expression is sensitive to hormonal treatments.
APPROVED FOR PUBLIC RELEASE