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Identification and Characterization of Factors that Affect Estrogen Receptor Transcriptional Activation in Breast Cancer
Annual rept. 1 Jul 2001-30 Jun 2002
NEW YORK UNIV NY SCHOOL OF MEDICINE
Pagination or Media Count:
Nearly half of human breast cancers are dependent on estrogen for growth. How estrogens stimulate cell growth is not understood. Estrogens activate an intracellular protein, the estrogen receptor ER, which acts together with certain receptor-interacting proteins to switch on some genes involved in cellular proliferation. The goal of thisproject is to identify and elucidate the roles of such receptor-interacting proteins in ER function. I have identified three proteins that interact with the ER using the yeast two-hybrid system, including the Vitamin D receptor-interacting protein 150 DRIPl5O, subunit of a nuclear receptor coactivator complex. I am currently defining the effects of DRIPl5O on ER transcriptional activity using a transient transfection system designed to monitor ER- dependent transcriptional activation.
APPROVED FOR PUBLIC RELEASE