Fas/FasL System in c-Myc Expressing Mammary Carcinoma Cells
Annual summary rept. 1 Jun 2001-31 May 2002
GEORGETOWN UNIV WASHINGTON DC
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The c-myc oncogene is thought to play an important roles in the onset and progression of breast cancer, where it is amplified in approximately 15 and overexpressed in over 60 of human breast cancers. Depending upon the availability of survival factors, cells that constitutively express c-Myc undergo proliferation, growth arrest, or apoptosis through as yet poorly defined mechanisms. Currently the molecular mechanism by which c-Myc sensitizes cells to apoptosis is not fully understood, nor are the environmental conditions in c-Myc-overexpressing mammary epithelium that promote apoptosis versus proliferation and transformation.
- Anatomy and Physiology
- Medicine and Medical Research