Accession Number:

ADA411302

Title:

Fas/FasL System in c-Myc Expressing Mammary Carcinoma Cells

Descriptive Note:

Annual summary rept. 1 Jun 2001-31 May 2002

Corporate Author:

GEORGETOWN UNIV WASHINGTON DC

Report Date:

2002-06-01

Pagination or Media Count:

72.0

Abstract:

The c-myc oncogene is thought to play an important roles in the onset and progression of breast cancer, where it is amplified in approximately 15 and overexpressed in over 60 of human breast cancers. Depending upon the availability of survival factors, cells that constitutively express c-Myc undergo proliferation, growth arrest, or apoptosis through as yet poorly defined mechanisms. Currently the molecular mechanism by which c-Myc sensitizes cells to apoptosis is not fully understood, nor are the environmental conditions in c-Myc-overexpressing mammary epithelium that promote apoptosis versus proliferation and transformation.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE