Accession Number:

ADA411298

Title:

Effects of Moderate Aerobic Exercise Combined With Caloric Restriction on Circulating Estrogens and IGF-I in Premenopausal Women

Descriptive Note:

Annual rept. 17 Sep 2001-16 Sep 2002

Corporate Author:

PENNSYLVANIA STATE UNIV UNIVERSITY PARK

Personal Author(s):

Report Date:

2002-10-01

Pagination or Media Count:

11.0

Abstract:

This study will test whether a program of moderate aerobic exercise that is combined with a moderate level of dietary restriction will result in significant decreases in two biomarkers of breast cancer, circulating estrogens and IGF-I. We will also test whether this type of dietexercise program will produce significant reductions in the peripheral production of estrone by adipose tissue through its impact on the reduction of fat mass. Lastly, validation studies for a novel method of assessing energy status will be performed. To date we have completed our first year of the three year study protocol. Our cohort for Year 1 consisted of 20 women 25-25 yrs divided into height 26-30 kgm2 and low BMI 21-15 kgm3 exercise groups. Aerobic exercise training was 4 times per week for four consecutive menstrual cycles at 77- 3 of maximum heart rate for 40-60 minutes, resulting in an average of 22 increase in aerobic capacity as defined by VO2 max P 0.05 pre vs post. Dietary intake was successfully reduced using the food exchange system Low BMI 1889 - 354 to 1214 239 kcals High BMI 2125 287 to 1450 264 kcals. The combination of moderate exercise and diet produced significant weight loss in both groups Low BMI - X High BMI - X P0.05. Significant changes in body composition occurred in both groups Low BMI 32 4 to 25 - 8 High BMI 39 - 5 to 32 - 6 P0.05. As expected, menstrual cycle length in these reproductively mature women did not change significantly with training and weight loss. We are currently conducting biochemical determinations of urinary estrone-3 glucuronide and pregnanediol-3 glucuronide, LH, and PSH, and serum IGF-1, Insulin, T3, Leptin, IGFbp-1, estrone and estradiol. Data reduction and analyses are being completed for dietary intake, energy expenditure, testing metabolic rate. We will begin recruiting for one Year 2 cohort in December, 2002.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research
  • Food, Food Service and Nutrition
  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE