Accession Number:

ADA411248

Title:

Optical Transillumination Spectroscopy of Breast Tissue to Determine the Cancer Risk in Pre- and Post-Menopausal Women

Descriptive Note:

Annual rept. 1 Jul 2001-1 Jul 2002

Corporate Author:

ONTARIO CANCER INST/PRINCESS MARGARET HOSPITAL TORONTO

Personal Author(s):

• Lilge, Lothar D.
• Wilson, Brian C.
• Jong, Roberta
• Yaffe, Martin
• Boyd, Norman

Report Date:

2003-08-01

Pagination or Media Count:

10.0

Abstract:

The objective of this study is to demonstrate a correlation between non-invasive optical transillumination spectroscopy and parenchymal density pattern, which are know to provide the highest odds ration for the risk of developing breast Cancer. The study includes pre- and post- menopausal women. Initial results indicate that optical transillumination spectroscopy can differentiate between high and low parenchymal density with sensitivity and specificity 90 for the study group n 225, after the introduction of stratification for the position on the breast. Additional analysis models the percent dense tissue area from the measured transillumination spectrum. A separate study investigates the influence of the menstrual cycle upon the transillumination spectra and no significant effects are noted. -

Descriptors:

• *TISSUES(BIOLOGY)
• *BREAST CANCER
• DENSITY
• OPTICAL PROPERTIES
• SPECTROSCOPY
• ILLUMINATION
• DIAGNOSIS(MEDICINE)
• WOMEN
• MAMMARY GLANDS
• RADIOLOGY
• CONNECTIVE TISSUE
• MENSTRUATION

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE