Accession Number:

ADA411023

Title:

Physiological Response in Ovis Aries Resulting from Electrical Stimuli Delivered by an Implantable Vision Prosthesis

Descriptive Note:

Corporate Author:

NEW SOUTH WALES UNIV SYDNEY (AUSTRALIA) SCHOOL OF BIOMEDICAL ENGINEERING

Report Date:

2001-10-25

Pagination or Media Count:

5.0

Abstract:

An implantable vision prosthesis has been developed to deliver externally controlled, charge balanced, constant current, biphasic electrical stimuli to the inner retina. The device is intended as a treatment to blindness. Specifically, degenerative disorders of the retina such as retinitis pigmentosa, macular degeneration, choroideremia, etc. would be treated with such a device. Many profoundly blind patients suffering from the aforementioned conditions are plagued with sleeping disorders associated with the loss of photic input. Restoration of light and dark perception may serve to restore circadian rhythm and thus this has been set as the initial goal for the device. In all effort to confirm the devices ability to provide light and dark perception all implantable electrode with a 3.9 mm2 contact area was inserted into the posterior eye chamber of the Ovis aries common name sheep. Using this electrode, stimuli from the implant were applied to the inner retina and all ensemble averaged evoked potential was successfully recorded from the visual cortex using sub-dural electrodes. This resulted in an electrically induced visual evoked potential with peak amplitude of 140 plus or minus 20 microvolts N3 that was qualitatively similar to a visual evoked potential evinced using stroboscopic light stimuli.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE