Accession Number:

ADA409999

Title:

Therapeutic and Chemopreventive Actions of a Novel Polyamine Analog Against Breast Cancer

Descriptive Note:

Final rept. 1 Sep 1999-31 Aug 2002

Corporate Author:

JOHNS HOPKINS UNIV BALTIMORE MD SCHOOLOF MEDICINE

Personal Author(s):

Report Date:

2002-09-01

Pagination or Media Count:

59.0

Abstract:

The intracellular polyamines, spermidine, spermine, and putrescine, play an important role in the proliferation and death of normal and malignant cells. As a consequence, our work has focused on development of inhibitors of this metabolic pathway. A phase II trial of diethylnorspermine DENSpm for women with advanced breast cancer was completed. No major toxicity was observed but clinical activity was not sufficient to warrant further testing of DENSpm at the dose and schedule used. Analysis of DENSpm- and control-treated breast cancer tumors derived from discarded mastectomy tissue showed that DENSpm can modulate expression of the SSAT enzyme on some specimens. This could potentially serve as a biomarker of effect The efficacy of several new polyamine analogs as treatment for established breast cancer in a nude mouse model xenograft has been demonstrated. Future studies will focus on these agents.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE