Accession Number:

ADA409903

Title:

Stretch Activated ION Channels in Myocytes: Parameter Estimation, Simulations and Phenomena

Descriptive Note:

Conference paper

Corporate Author:

KARLSRUHE UNIV (GERMANY F R)

Report Date:

2001-10-25

Pagination or Media Count:

6.0

Abstract:

Mechanosensitive ion channels influence the electrophysiological state of cardiac myocytes. An examination of the mechanisms of mechano-electrical coupling on cellular level by the mechanosensitive ion channels was performed. Simulations with a detailed electrophysiological model were carried out. Static stretch leaded to an increase of the resting potential and a decrease of the duration of the action potential with increasing sarcomere length. Dynamic stretch delivered a variety of phenomena depending on the duration and amplitude of the stretch. An arrhythmogenic single cell phenomenon, early afterdepolarisation, was observed.

Subject Categories:

  • Anatomy and Physiology
  • Electricity and Magnetism

Distribution Statement:

APPROVED FOR PUBLIC RELEASE