Accession Number:
ADA409903
Title:
Stretch Activated ION Channels in Myocytes: Parameter Estimation, Simulations and Phenomena
Descriptive Note:
Conference paper
Corporate Author:
KARLSRUHE UNIV (GERMANY F R)
Personal Author(s):
Report Date:
2001-10-25
Pagination or Media Count:
6.0
Abstract:
Mechanosensitive ion channels influence the electrophysiological state of cardiac myocytes. An examination of the mechanisms of mechano-electrical coupling on cellular level by the mechanosensitive ion channels was performed. Simulations with a detailed electrophysiological model were carried out. Static stretch leaded to an increase of the resting potential and a decrease of the duration of the action potential with increasing sarcomere length. Dynamic stretch delivered a variety of phenomena depending on the duration and amplitude of the stretch. An arrhythmogenic single cell phenomenon, early afterdepolarisation, was observed.
Subject Categories:
- Anatomy and Physiology
- Electricity and Magnetism