Accession Number:

ADA409884

Title:

A Model of Gap Junction Conductance and Ventricular Tachyarrhythmia

Descriptive Note:

Corporate Author:

ZHEJIANG UNIV SCHOOL OF MEDICINE HANGZHOU (CHINA) DEPT OF PHYSIOLOGY

Report Date:

2001-10-25

Pagination or Media Count:

5.0

Abstract:

Cardiac gap junctions CJs form low resistance pathways along which the electrical impulse flows rapidly and repeatedly between all the cells of the myocardium, enabling coordinated contraction of the heart, In many heart diseases, electrical coupling through GJ channels between cardiomyocytes is down regulated, We set up a mathematical model of a chain of myocardial fibers to study how changing the coupling affects the activity of autorhythmic myocytes, While uncoupling blocked the propagation of excitation from autorhythmic Myocytes to surrounding quiescent but excitable cells, different degrees of uncoupling increased the automaticity of the cells, Our modeling data suggests that the number of autorhythmic cells plays a key role in the excitation of autorhythmic cells and the conduction of impulses, We conclude that the degree of uncoupling between cardiomyocytes, induced by pathological processes, may generate ectopic foci, tachyarrhythmias being the outcome,

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE