Accession Number:

ADA409881

Title:

Effect of Calcium-Activated Chloride Current Blockade on the Delayed Afterdepolarizations. Simulation Study

Descriptive Note:

Corporate Author:

UNIVERSIDAD POLITECNICA DE VALENCIA (SPAIN) LABORATORIO INTEGRADO DE BIOINGENIERIA

Personal Author(s):

Report Date:

2001-10-25

Pagination or Media Count:

5.0

Abstract:

High intracellular calcium conditions cause a calcium-activated transient inward current I to the ti that can provoke oscillations in membrane potential called delayed afterdepolarizations DAD. The current I to the ti comprises of the sodium-calcium exchange current I to the CI-Ca and the calcium activated chloride current 1ci-ca Lindblad, Murphey, Clark and Ciles developed a mathematical model LMCC model of the rabbit atrial AP, In this study, a modified AP LMCC model that includes I to the ci-ca is used to evaluate the contribution of I to the ci-ca to develope DADs, Our results suggest that although I to the NaCa is the main component of I to the ti 65 , I to the ci-ca may play a significant role in DAD generation, Even more, the I to the ci-ca blockade could inhibit the DAD propagation and trigger activity associated to high Ca2 condition, in atrial tissue,

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE