The Role of the Insulin-Like Growth Factor (IGF) Binding Proteins (IGFBPs) in IGF-Mediated Tumorigenicity
Annual summary rept. 1 Jul 2001-30 Jun 2002
MEDICAL UNIV OF SOUTH CAROLINA CHARLESTON
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The insulin-like growth factor IGF system has been shown to play an important role in the progression of a number of cancers, including breast cancer. IGF-1 binds with high affinity to a family of proteins known as the IGF binding proteins IGFBPs, which act as natural inhibitors of IGF-1 through sequestration from the IGF-1 receptor. The purpose of this proposal is the development of IGF antagonists based on the structure of the IGFBPs. Knowledge of the mechanism of IGFBP action is currently unclear, therefore we have taken a photoaffinity labeling approach to identify the IGF binding domains on the IGFBPs.
- Medicine and Medical Research