Accession Number:

ADA409794

Title:

Quantification of Transmural Differences in Myocardial Function with MRI Tagging

Descriptive Note:

Research rept.

Corporate Author:

MAASTRICHT UNIV (NETHERLANDS) CARDIOVASCULAR RESEARCH INST

Report Date:

2001-10-25

Pagination or Media Count:

4.0

Abstract:

Many cardiac diseases cause transmural differences in myofiber function. With the Magnetic Resonance Imaging Tagging technique a grid of magnetic tags was attached to the heart. Using a model of cardiac mechanics the motion of these tags was analyzed to deduct the transmural gradient of myofiber shortening. In normal, young healthy subjects n9, the transmural difference in myofiber shortening varies little, about or - 4 standard deviation of mean shortening. In patients with aortic stenosis subendocardial function is at risk. In a group of such patients n5 fiber shortening in the subendocardial layers was found to be decreased by 23 or - 20 relative to the subepicardial layers. This finding indicates that a model of cardiac mechanics can be used as a tool to convert MRI-tagging motion data to clinically useful information on a transmural gradient in contractile function. Presently, no other methods are available to detect such a transmural gradient noninvasively. 1 figure, 8 references

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE