Accession Number:

ADA409740

Title:

Organosulfur Compounds as ChemDefense Agents - Mustard

Descriptive Note:

Midterm rept. 21 Feb 2000-31 Aug 2001

Corporate Author:

DENVER UNIV CO

Personal Author(s):

Report Date:

2001-09-01

Pagination or Media Count:

45.0

Abstract:

Organosulfur compounds have demonstrated protective activity against sulfur mustard HD, bis2-chloroethyl sulfide. Twenty three compounds, many representing new compositions of matter, have been prepared in the first half of this program. These include derivatives of thiavitamin E, glutathione, thiacholesterol, pyridine and benzothiazole. The program has expanded the ability to prepare unsymmetric disulfides of interest and the utility of 2- mercaptobenzothiazole and alkoxycarbonylsulfenyl chlorides in this program. These compounds, largely based upon monothiols, form the platform upon which to develop targets related to BAL and related systems. We currently are awaiting details of bioassay studies.

Subject Categories:

  • Chemical, Biological and Radiological Warfare

Distribution Statement:

APPROVED FOR PUBLIC RELEASE