Accession Number:

ADA409696

Title:

Mechanisms of Virus-Induced Neural Cell Death

Descriptive Note:

Annual rept. 15 Aug 2001-14 Aug 2002

Corporate Author:

COLORADO UNIV HEALTH SCIENCES CENTER DENVER

Personal Author(s):

• Tyler, Kenneth L.

Report Date:

2002-09-01

Pagination or Media Count:

123.0

Abstract:

Virtually all known neurotropic viruses are capable of killing infected cells by inducing a specific pattern of cell death known as apoptosis, yet the mechanism by which this occurs and its relevance to human disease remain largely unknown. We have shown that apoptosis is an important feature of human CNS viral infections including herpes simplex virus and cytomegalovirus encephalitis, and PML.

Descriptors:

• *NERVE CELLS
• *VIRUS DISEASES
• *DEATH
• *CELLS(BIOLOGY)
• *MITOCHONDRIA
• ACTIVATION
• HUMANS
• IN VITRO ANALYSIS
• SEQUENCES
• PATTERNS
• THERAPY
• GENES
• ANIMALS
• INFECTIOUS DISEASES
• ANTIVIRAL AGENTS
• IN VIVO ANALYSIS
• ENCEPHALITIS
• PATHOGENESIS
• CENTRAL NERVOUS SYSTEM
• RECEPTOR SITES(PHYSIOLOGY)
• BLOOD PROTEINS
• CASCADE STRUCTURES
• HERPES SIMPLEX VIRUS
• CYTOMEGALOVIRUS
• REOVIRUSES
• APOPTOSIS

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE