Accession Number:

ADA409676

Title:

Spectral Changes of Lung Cancer Serum in the Process of Tumor Evolution

Descriptive Note:

Corporate Author:

LIAONING UNIV (CHINA) DEPT OF BIOLOGY

Report Date:

2001-10-25

Pagination or Media Count:

6.0

Abstract:

The discrimination and changes of serum fluorescence and Raman spectrum for normal human, lung cancer patient and one after operation in different period and extent were studied. We kept close watch on the tumor progression of a group of patients, and measured their serum spectra using 488.0nm and 514.5nm excitation of an Ar-ion laser once a week. There was no apparent change observed in fluorescence spectrum in different period. However, the relative intensity of three Raman peaks mode A, B, and C decreased every week later. For quantitative analysis of such changes, a parameter Isub r relative intensity of C Raman peak was introduced and Isub r-value was calculated. Calculation showed that Isub r-value was digressive with tumor evolution, but caret-a I sub r5145I sub 4880 varied irregularly. To the end, no Raman peak was observed. We assumed that three Raman peaks were derived from beta carotene. It indicated that the content of beta carotene decreased with the aggravation of lung cancer.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE