Accession Number:

ADA409607

Title:

The Role of Stat3 in Breast Cancer Tumorigenesis

Descriptive Note:

Final rept. 20 Aug 2001-19 Aug 2002

Corporate Author:

SLOAN-KETTERING INST FOR CANCER RESEARCH NEW YORK

Personal Author(s):

Report Date:

2002-09-01

Pagination or Media Count:

9.0

Abstract:

Signal Transducers and Activators of Transcription STATs are a family of transcription factors which are normally inactive within the cytoplasm of cells and upon tyrosine phosphorylation become activated1 which leads to the dimerization of two Stat molecules. Dimerized Stats are translocated into the nucleus where they bind DNA and activate transcription. Stat dimers are dephosphorylated within the nucleus and transported back to the cytoplasm 1. Virtually all growth factor receptors, cytokines, and tyrosine kinases lead to the phosphorylation of one or more Stat proteins. In normal cells this activation is transient, while in an ever growing number of primary tumors and cancer derived cell lines Stat proteins in particular Stat3 are constitutively activated 1, 2. A causal association between activated Stat3 and cellular transformation or oncogenesis has been made in a large number of cancer derived cell lines. Specifically, removal of Stat3 by the introduction of a dominant negative Stat3 molecule or anti-sense molecule leads to a reversal of the transformed phenotype, induction of apoptosis , decreased angiogenesis or growth arrest Figure 1.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE