Accession Number:

ADA409399

Title:

Identification and Characterization of Novel Antimitotic Compounds for the Treatment of Breast Cancer

Descriptive Note:

Final rept. 15 Jul 1999-15 Jul 2002

Corporate Author:

BRITISH COLUMBIA UNIV VANCOUVER

Personal Author(s):

Report Date:

2002-08-01

Pagination or Media Count:

40.0

Abstract:

Antimitotics are drugs that kill cancer cells by causing them to arrest in mitosis. Antimitotics currently used in breast cancer therapy include paclitaxel, vincristine and vinbiastine. Although these drugs are extremely valuable, they are not ideal because they have serious side effects, and, most importantly, many breast cancers are resistant to them. Our goal was to find new antimitotic drugs for the treatment of breast cancer using a novel cell-based assay to screen natural product libraries and guide the purification of their active components.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE