Noninvasive Detection of Microdamage in Bone
Annual rept. 10 Sep 2001-10 Sep 2002
RUSH-PRESBYTERIAN-ST LUKE'S MEDICAL CENTER CHICAGO IL
Pagination or Media Count:
This concept exploration proposal seeks to determine if a novel x-ray technique called diffraction enhanced imaging, which provides dramatic gains in contrast over conventional radiography, can be used to identify microdamage in bone non-invasively. This technique has been used successfully in soft tissues, including recent studies by our group to detect damage in articular cartilage. Here, we plan to extend our work to studies relevant to microdamage accumulation and repair in bone. Interest in microdamage in bone comes in part from its likely role in the etiology of stress fractures. In addition, microdamage accumulation may contribute to osteoporotic fractures and loosening of dental or orthopedic implants. Our working hypothesis is that microdamage in bone can be detected non-invasively by diffraction enhanced imaging because this imaging modality expands the ability of x-rays to record refraction and scatter rejection extinction as well as absorption. No matter the spatial scale of the fracture feature, diffraction enhanced imaging has a contrast mechanism suited to make the feature visible. We have performed two sets of experiments to address Specific Aim 1, which focuses on using machined bone samples to determine if induced microdamage can be detected non- invasively. The results suggest that this may be possible and we are currently designing and carrying out an additional experiment to confirm these observations.
- Medicine and Medical Research
- Nuclear Physics and Elementary Particle Physics