Paralysis in Nerve Agent Toxicosis in Guinea Pigs
DEFENCE RESEARCH AND DEVELOPMENT SUFFIELD (ALBERTA)
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Since the discovery of the G-type nerve agents, there have been numerous studies of Central Nervous System CNS involvement in the etiology of organophosphate poisoning, notably associated with status Elipticus andor electrographic seizures. Brain damage from these effects has been demonstrated as neuronal necrosis primarily in the cortex, thalamus and hippocampus. However, despite recurring references to CNS damage, to the authors knowledge there have been no reports of long term paralysis manifested within 24 hr of nerve agent exposure. Occasional paralysis following an asymptomatic time interval of 7-14 days has been reported. This report is intended to summarize the immediate, nerve agent induced paralytic events recorded in guinea pigs as incidental observations during development of the Canadian Reactive Skin Decontaminant Lotion RSDLR. Because the experiments were designed to assess the decontamination procedures, there were no apparent relationships between the amounts of agent applied and the sequellae recorded.
- Medicine and Medical Research
- Chemical, Biological and Radiological Warfare