Accession Number:

ADA409210

Title:

Cell-Specific Ionic Models of Cardiac Pacemaker Activity

Descriptive Note:

Corporate Author:

NEW SOUTH WALES UNIV SYDNEY (AUSTRALIA) SCHOOL OF BIOMEDICAL ENGINEERING

Report Date:

2001-10-25

Pagination or Media Count:

3.0

Abstract:

We have developed a generic ionic model of single-cell rabbit sinoatrial node SAN electrical activity, employing Markov-state kinetics for membrane ionic currents. By suitable choice of parameters, the model is able to accurately reproduce a wide range of action potential waveforms recorded from individual SAN cells in the laboratory. Advantages of this approach include the ability to quantitatively investigate the contribution of ion currents underlying pacemaker and action potential activity from any given SAN myocyte recording.

Subject Categories:

  • Anatomy and Physiology
  • Medical Facilities, Equipment and Supplies

Distribution Statement:

APPROVED FOR PUBLIC RELEASE