Accession Number:

ADA409105

Title:

Effect of Time of Menstrual Cycle on Drug Pharmacokinetics and Pharmacodynamics

Descriptive Note:

Final rept. 1 Sep. 1997-1 May 2001

Corporate Author:

WALTER REED ARMY INST OF RESEARCH SILVER SPRING MD

Personal Author(s):

Report Date:

2001-05-01

Pagination or Media Count:

108.0

Abstract:

Gender has been shown to influence a number of pharmacokinetic variables including, serum protein binding 1, absorption rate 2, peak plasma concentration and area under the curve 3, and drug clearance 4 - A number of factors may contribute to gender differences in drug disposition including, differences in body composition, the use of oral contraceptives, plasma levels of the sex hormones, and the phases of the menstrual cycle 5,6. To date very few studies have actually examined the effects of the time of the menstrual cycle follicular, ovulatory, luteal on the pharmacokinetics and concomitant pharmacodynamics of a drug.

Subject Categories:

  • Biology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE