Accession Number:

ADA406700

Title:

Pokeweed Antiviral Protein as an Universal Virus Neutralizer

Descriptive Note:

Final progress rept.

Corporate Author:

PARKER HUGHES INST SAINT PAUL MN

Personal Author(s):

Report Date:

2002-01-01

Pagination or Media Count:

100.0

Abstract:

The objective of this project is to develop strategies which will allow the use of recombinant mutant pokeweed antiviral protein PAP as a potential countermeasure against biological warfare attempts employing pathogenic viruses. In order to increase the therapeutic index of the naturally occurring PAP, recombinant PAP mutants with superior antiviral activity and low toxicity will be constructed. The recombinant PAP mutants will be designed using the state-of-the-art technologies including X-ray crystallography, computer modeling, rational protein design and protein engineering.

Subject Categories:

  • Pharmacology
  • Chemical, Biological and Radiological Warfare

Distribution Statement:

APPROVED FOR PUBLIC RELEASE