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Non-Invasive Monitoring of Breast Tumor Oxygenation: A Key to Tumor Therapy Planning and Tumor Prognosis
Annual rept. 1 Sep 2000-31 Aug 2001
TEXAS UNIV AT ARLINGTON
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The goal of this research project is to develop and evaluate a new approach to monitoring of vascular hemoglobin oxygen saturation SO2 and oxygenated hemoglobin HbO2 concentration of breast tumors using near infrared NIR spectroscopy and imaging techniques. We have evaluated a single-channel, dual wavelengths, NIR, frequency-domain oximeter and the corresponding algorithm for obtaining tumor SO2 and HbO2 under carbogen intervention against tumor P02 measurement using NIRS and needle type P02 electrodes, and the P02 data were supported by the 19F MR P02 mapping. The NIRS data showed significant changes in vascular oxygenation accompanying respiratory interventions, and changes in tumor vascular hemoglobin oxygenation preceded tumor tissue P02. A combined algorithm has been developed for quantifying absolute deoxygenated Hb, oxygenated Hb, and total Hb concentrations, and this algorithm is particularly developed for our single source-detector separation, two wavelengths, NIR, frequency-domain system. With this algorithm, we are able to obtain relatively accurate results of total Hb concentrations with possible scattering variations.
APPROVED FOR PUBLIC RELEASE