Accession Number:

ADA399915

Title:

Analysis of Investigational Drugs in Biological Fluids - Method Development and Analysis of Pre-Clinical Samples

Descriptive Note:

Annual rept. 11 Aug 2000-10 Aug 2001

Corporate Author:

CALIFORNIA UNIV SAN FRANCISCO

Personal Author(s):

• Lin, Emil T.

Report Date:

2001-09-01

Pagination or Media Count:

127.0

Abstract:

Work on development andor validation of analytical methodologies during the current contract focused on assays for WR 6026 and its metabolites, WR 211789 and WR 254421, mefloquine and its metabolite, WR 160972, p-aminoheptanophenone and related compounds, WR 242511, halofantrine and its metabolite, WR 178,460, and their stereoisomers, chloroquine and its metabolites, monodesethylchoroquine and didesethyichloroquine, WR 243,251, WR 238,605, gentamicin, paromomycin and artelinic acid and metabolites and artesunate. Work on routine analyses of biological specimens during this period was performed for studies that required determination of concentrations of artelinic acid, choroquine and its metabolites, monodesethyichloroquine and didesethylchloroquine, and stereoisomers of halofantrine and its metabolite, WR 178,460.

Descriptors:

• *CLINICAL MEDICINE
• *DRUGS
• *STEREOCHEMISTRY
• *BODY FLUIDS
• VALIDATION
• BIOLOGY
• SAMPLING
• MOLECULAR ISOMERISM
• REPRODUCIBILITY
• METABOLITES
• ANTIBIOTICS
• BIOASSAY
• CHLOROQUINE

Subject Categories:

• Biochemistry
• Medicine and Medical Research
• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE