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Accession Number:
ADA399541
Title:
Protein-Based Three-Dimensional Memories
Descriptive Note:
Final technical rept. Jun 1998-Jun 2000
Corporate Author:
SYRACUSE UNIV NY OFFICE OF SPONSORED PROGRAMS
Report Date:
2002-01-01
Pagination or Media Count:
152.0
Abstract:
Significant progress has been made in the remaining tasks, specifically materials development, protein optimization, computer interface development, and prototype development. The primary goal of the materials effort was to develop a polymer matrix for encapsulation of the protein, characterized by optical clarity, long-term stability, protein compatibility, and resistance to gel dehydration and contraction. Handled via subcontract to Wayne Wang of Carleton University in Ottawa, Canada, a polyacrylamide based hydrogel has been developed that fits the majority of these characteristics. Light scattering was achieved primarily by the addition of refractive index-matching agents, with sucrose achieving the best reduction. A newly developed high-density acrylamide matrix demonstrates the largest reduction of light scattering, by roughly one order of magnitude over previous gels. Optimization of the protein response was approached primarily through site-directed mutagenesis SDM, with the goal of increasing the efficiency with which the branched photocycle can be assessed two avenues were explored to this end, including enhancement of the 0-state yield and the quantum yield of the 0- P transition. The former avenue increases the amount of P-state formed through simple mass transfer-a higher yield of 0 will result in more P formation, despite the 0- P quantum efficiency. The latter approach seeks to directly increase the 0- P quantum efficiency.
Distribution Statement:
APPROVED FOR PUBLIC RELEASE
