Stage I Breast Cancer and Bone Mass in Older Women
Annual rept. 1 Oct 2000-1 Oct 2001
CALIFORNIA UNIV SAN DIEGO LA JOLLA
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The specific aims of the study are I to assess the bone mineral density of women 65 years of age and older with breast cancer in comparison with the bone mineral density of same aged women with normal mammograms 2 to examine the risk factors associated with breast cancer and low bone mass in these two groups of women 3 to develop a model based on the study population to determine the predictive value of low bone mass for risk of breast cancer. During the three years of this study, a total of 300 women 150 with breast cancer and 150 with a normal mammogram aged 65 and older will be recruited from oncology and radiology offices to participate in a study consisting of one clinic visit. At the clinic visit, each subject will complete questionnaires detailing medical history, health habits, reproductive history, and medications. Height and weight will be measured. A blood sample will be drawn for storage. Bone mineral density will be measured at the forearm, hip, lumbar spine Ll-L4, and whole body using dual energy x-ray absorptiometry DXA. The results of this study can be used I to identify the likelihood of low bone mass in older women with breast cancer 2 to identify the risk factors that are common to both low BMD and breast cancer and 3 to determine the feasibility of discontinuing mammography after 65 in women with low bone mass.
- Anatomy and Physiology
- Medicine and Medical Research