Low-Level Sarin Neurotoxicity and Its Modulation by Pyridostigmine
Annual rept. 30 Sep 2000-29 Sep 2001
CALIFORNIA UNIV DAVIS
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The possibility that a combination of exposure to organophosphate esters OPs and the carbamate pyridostigmine bromide PB led to neurological symptoms claimed to a low-grade organophosphate induced delayed neuropathy, OPIDN in Gulf War veterans is under experimental study. Animals hen, mouse are treated with diisopropyl fluorophosphate DFP or sarin GB in the presence or absence of PB. We established subthreshold and threshold levels for the induction of OPIDN in hens repeatedly treated with TOCP or DFP. Preliminary findings suggest increased nerve damage when DFP-treated hens are concurrently treated with PB. In the mouse, large single doses of TOCP failed to induce clinical or pathological signs of OPIDN.
- Medicine and Medical Research
- Chemical, Biological and Radiological Warfare